Studies on Pure Red Cell Aplasia . XI
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چکیده
Thirty-seven patients with pure red cell aplasia (PRCA) were seen between 1 966 and 1 982. Ten patients had accompanying diseases described in association with PRCA, while the remainder had primary PACA. All but two patients were treated with some form of immune manipulation. including corticosteroids. cytotoxic drugs. antithymocyte globulin. splenectomy. thymectomy. and plasmapheresis. Twenty-three patients (66%) had a remission induced by immunosuppression. In addition, there were 5 spontaneous remissions (14%). Cytotoxic drugs administered in combination with corticosteroids were the most effective form of treatment. producing 1 8/32 remissions (56%). Twelve of these remissions were in patients resis-
منابع مشابه
Studies on Pure Red Cell Aplasia . XI . Results
Thirty-seven patients with pure red cell aplasia (PRCA) were seen between 1 966 and 1 982. Ten patients had accompanying diseases described in association with PRCA, while the remainder had primary PACA. All but two patients were treated with some form of immune manipulation. including corticosteroids. cytotoxic drugs. antithymocyte globulin. splenectomy. thymectomy. and plasmapheresis. Twenty-...
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Linezolid (LZD), severed as the first oxazolidinone antibiotic, was active against multidrug-resistant gram-positive strains. LZD can induce thrombocytopenia, anemia and leukocytopenia. Currently, reports on pure red cell aplasia (PRCA) cases induced by LZD are relatively rare [4-7]. In this paper, we reported a patient with PRCA twice induced by LZD. A 37-year-old man was diagnosed with myelody...
متن کاملLinezolid Induced Twice Pure Red Cell Aplasia in a Patient with Central Nervous System Infection after Allogeneic Stem Cell Transplantation
Linezolid (LZD), severed as the first oxazolidinone antibiotic, was active against multidrug-resistant gram-positive strains. LZD can induce thrombocytopenia, anemia and leukocytopenia. Currently, reports on pure red cell aplasia (PRCA) cases induced by LZD are relatively rare [4-7]. In this paper, we reported a patient with PRCA twice induced by LZD. A 37-year-old man was diagnosed with myelody...
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6. Peschle C, Marmont AM, Marone G, Genovesi A, Sasso G, Condorelli M: Pure red cell aplasia: Studies on an IgG serum inhibitor neutralizing erythropoietin. Br I Haematol 30:405, 1975 7. Krantz SB: Studies on red cell aplasia. III. Treatment with horse antihuman thymocyte gamma globulin. Blood 39:347, 1972 8. Marmont AM, Peschle C, Sanguineti M, Condorelli M: Pure red cell aplasia (PRCA): Respo...
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Pure red cell aplasia is a rare cause of anemia, caused by an absence of red blood cell precursors in the bone marrow. It is usually a paraneoplastic syndrome, associated most commonly with large-cell granular lymphocyte leukemia but also thymoma. For patients who present both pure red cell aplasia and thymoma, thymectomy leads to an initial remission of the aplasia in 30% of cases. However, su...
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تاریخ انتشار 2005